A One Health approach for better health solutions

Malaria, a disease caused by the bite of a certain type of mosquito, is preventable and usually treatable. Yet the World Health Organization estimated that in 2020 there were 241 million cases of malaria which resulted in 627,000 deaths.

Doctors can prescribe preventive and curative drugs, but they cannot prevent the disease from spreading among the mosquito population and posing a risk to populations with limited access to health care.

“To do something about malaria, you need to understand the ecology of Anopheles mosquitoes, their interactions with humans, and the environmental conditions that contribute to the spread of the disease,” said Frank A. von Hippel, PhD, One Health expert at Arizona University of Health Sciences and professor at UArizona Mel and Enid Zuckerman College of Public Health. “This applies to thousands of diseases where human health, animal health and environmental health jurisdictions overlap.”

A recent example is COVID-19. Like malaria, COVID-19 is a zoonic disease, which means it can spread from an animal host to people and from people to animals. But unlike malaria, COVID-19 is contagious between humans.

“In order to understand both the current pandemic and to predict and prevent future pandemics, you need to understand the ecology of the system,” Dr von Hippel said. “In the case of COVID-19, this includes the ecology of bats that harbor the virus, how this virus can ecologically jump to humans, and how it spreads.”

Frank von Hippel, PhD promotes a One Health approach to research by connecting UArizona health science experts with colleagues across the university to improve health outcomes for all.Capturing each of these factors is too heavy a task for a single expert or a single area of ​​research. To fully understand the complexities and interconnections between people, animals, plants and the environment, a more collaborative approach to research is needed.

To that end, UArizona Health Sciences supports a campus-wide One Health research initiative, led by Dr. von Hippel. By integrating human, animal and environmental health expertise, One Health aims to improve health outcomes, better respond to public health challenges, ensure safe and healthy food and water, and protect global health security.

The Ultimate One Health Topic

A trip to a local grocery store or farmer’s market has far greater health implications than one might think, including the availability of healthy food. Indeed, our food system is very complex, according to Kerry Cooper, Ph.D.assistant professor in the School of Animal and Comparative Biomedical Sciences at the UArizona College of Agriculture and Life Sciences and a member of the BIO5 Institute.

In lettuce fields, animal manure can contaminate soil or irrigation water with E. coli, which can pose a serious risk to human health.  The outbreaks of E.  coli in romaine lettuce are a recent example of why Kerry Cooper, PhD, believes food safety is One Health's ultimate topic.The products we eat are usually grown on farms, where contaminants in the soil and other environmental conditions can threaten the safety of our food, Dr. Cooper explained. Water used to grow plants can also pose its own threats. Local water sources are essential not only for the growth of crops, but also for the survival of wildlife such as birds, insects and other animals which can also include livestock.

Each aspect of the cycle can be further disrupted by human-caused environmental changes – pollution, for example – that affect the food supply.

“There are a lot of things that go into food safety that most people don’t think about,” Dr. Cooper said. “That’s why I see food safety as the ultimate subject of One Health.”

A more complete story

Kristen Pogreba-Brown PhD, MPH, an associate professor at the Zuckerman College of Public Health, has championed the One Health approach for several years. As an infectious disease epidemiologist, she sees One Health as essential to solving “tough issues” like pandemics, antibiotic resistance and water security.

Kristen Pogreba-Brown PhD, MPH, says she began discussing the One Health approach with her campus colleagues as early as 2014.“These are very big problems that we’re not going to solve with one entity or one discipline,” said Dr. Pogreba-Brown, who teaches an applied One Health course at Zuckerman College of Public Health. “We’ve been working locally for years, but now we’re starting to look more seriously at collaborations and opportunities to address these issues together.”

Drs. Brown and Cooper have combined their joint expertise in the area of ​​foodborne illness for several years.

“Kerry says he doesn’t want to talk to people and investigate them for a living, and I don’t want to collect fecal samples,” Dr Pogreba-Brown said. “That’s one of the things that makes us good collaborators.”

Dr. Pogreba-Brown’s research can gather information from people, such as what someone ate before they got sick, while Dr. Cooper’s research can confirm whether the bacteria that caused the illness came from the source. reported by the patient.

“She’s the epidemiologist, I’m the microbiologist,” Dr. Cooper said. “We can combine his data and my data to get a much more complete story.”

A holistic approach

At the inaugural UArizona Health Sciences One Health Symposium in May, Kate Worthing, BVSc, PhDdescribed what a veterinarian can bring to a One Health team.

“The idea is to break down research silos.”

Frank A. von Hippel, PhD

“A veterinarian thinks about the humans who are associated with an animal and the environment shared by humans and the animal,” said Dr. Worthing, assistant professor of practice at the UArizona College of Veterinary Medicine. “It’s this lateral thinking and holistic approach that makes vets such great team members.”

Drs. Worthing, Cooper and Pogreba-Brown are laying the foundation for stronger collaborations, especially in the area of ​​food safety and foodborne diseases that affect animals and humans.

Dr. Worthing also wants to work with Dr. Pogreba-Brown and other public health researchers to study One Health approaches to animal shelters. They hypothesize that animal shelters could serve as a useful model for infection control in human long-term care facilities.

New research opportunities

(Left to right) Frank A. von Hippel, PhD, was joined by Daniel Derksen, MD, UArizona Health Sciences associate vice president for health equity, outreach, and interprofessional activities, and Michael D. Dake, MD, Senior Vice President for Health Sciences, in welcoming researchers from across campus to the One Health Symposium in May.One Health Symposium attendees also listened to Dr. Pogreba-Brown present the research she and her graduate students are conducting on the impact of the pandemic on conditions at the Pima Animal Care Center (PACC). Her class has conducted needs assessments and other projects with PACC through the implementation of a One Health model.

“Everyone wants to make evidence-based decisions,” said BIO5 Institute Fellow Dr. Pogreba-Brown. “But first you have to have the evidence.”

If researchers can demonstrate that One Health approaches to animal care are effective, it could attract federal funds to initiate studies and implement new policies in human health care.

“The idea is to break down research silos,” said Dr. von Hippel. “We have many research groups on campus working on one or two aspects of One Health, but usually not all three. The expertise is there, you just have to bring everyone together.

The next UArizona One Health Symposium will take place September 28 and will feature Linda Birnbaum, PhD, former director of the National Institute of Environmental Health Sciences and National Toxicology Program, as keynote speaker.

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